john herr psychologist los gatos saratoga california

On Sabbatical

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TITLE: Alloxan diabetes abolishes the increased negativity of interstitial fluid pressure in rat trachea induced by vagal nerve stimulation.
AUTHOR: Woie K; Reed RK
AUTHOR AFFILIATION: Department of Physiology, University of Bergen, Norway.
SOURCE: Acta Physiol Scand 1997 Sep;161(1):113-9
NLM CIT. ID: 98017776
ABSTRACT: Increased negativity of interstitial fluid pressure (Pif) occurs concomitantly with oedema formation in acute airway inflammation. This observation is principally important because the loose connective tissues become 'active' and provide the driving force for the rapid oedema formation via Pif. The present study reports Pif in acute airway inflammation in alloxan diabetic rats. The basis for the study was, firstly, that inflammation is important in the pathogenesis of asthma. Secondly, that clinically there is almost a mutual exclusion between diabetes and asthma and, lastly, that the inflammatory response is attenuated in alloxan diabetic rats. Pif was measured on the ventral side of the trachea with sharpened glass capillaries (3-6 microns) connected to a servocontrolled counterpressure system. Measurements and nerve stimulation were performed after circulatory arrest, since oedema formation associated with inflammation will increase Pif, causing an underestimation of a potentially increased negativity of Pif. Control or diabetic rats (alloxan 45 mg kg-1 i.v. 5 days earlier) received either the mast cell degranulating substance compound 48/80 (100 micrograms), dextran 70 (60 mg) i.v. or vagal nerve stimulation. After dextran, Pif was -4.7 +/- 0.9 (SD) mmHg (n = 6) and -1.3 +/- 0.3 mmHg (n = 6) (P <0.01) in normal and diabetic rats, respectively. Corresponding values after vagal nerve stimulation were 5.3 +/- 1.8 mmHg (n="5)" and 0.7 +/- 0.2 mmHg (P < 0.01). Insulin treatment restored the Pif response to dextran and vagal stimulation. Pif after Compound 48/80 did not differ between control and diabetic rats. Interstitial volume, total tissue water and transcapillary albumin extravasation increased significantly in controls after vagal nerve stimulation, but was attenuated in diabetic rats.
MAIN MESH SUBJECTS: Diabetes Mellitus, Experimental/DRUG THERAPY/*PHYSIOPATHOLOGY
Extracellular Space/*PHYSIOLOGY
Trachea/IMMUNOLOGY/*INNERVATION
Tracheitis/COMPLICATIONS/*IMMUNOLOGY
Vagus Nerve/DRUG EFFECTS/*PHYSIOLOGY
ADDITIONAL MESH SUBJECTS: Albumins/METABOLISM
Alloxan
Animal
Blood Glucose
Cytoplasmic Granules/DRUG EFFECTS
Edema/ETIOLOGY/IMMUNOLOGY
Extravasation of Diagnostic and Therapeutic Materials
Hypoglycemic Agents/PHARMACOLOGY
Insulin/PHARMACOLOGY
Mast Cells/DRUG EFFECTS/METABOLISM
Plasma Volume
Potassium Chloride/PHARMACOLOGY
Pressure
Rats
Rats, Wistar
Stimulation, Chemical
Support, Non-U.S. Gov't
Water/METABOLISM
PUBLICATION TYPES: JOURNAL ARTICLE
LANGUAGE: Eng
REGISTRY NUMBERS: 0 (Albumins)
0 (Blood Glucose)
0 (Hypoglycemic Agents)
11061-68-0 (Insulin)
50-71-5 (Alloxan)
7447-40-7 (Potassium Chloride)
7732-18-5 (Water)

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On Sabbatical!

When my office lease expired at the end of 2004, I decided to turn it into a "sabbatical" from my private practice. Many years ago, in my grandfather's 89th year of life, he told me, "John, it is important to smell the roses while you can still smell them." His life gave living a very good reputation. It is also true that the pursuit of that philosophy required my grandfather to to re-open his assay office/ore market in Wickenburg, Arizona as a 75-year-old because he had run a little short of retirement money. Thus, if blessed with his luck and health, I'll be back.. --jjh

Copyright 1998-2007  John J. Herr, Ph.D.                                   Please send comments to jjherr@clinicalpsychologist.com